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Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts.

Hüffmeier U, Traupe H, Burkhardt H, Schürmeier-Horst F, Lascorz J, Böhm B, Lohmann J, Ständer M, Wendler J, Kelsch R, Baumann C, Küster W, Wienker TF, Reis A

Institute of Human Genetics, University Erlangen-Nuremberg, Nuremberg, Germany.

A DNA variant, rs734232, altering a RUNX1 binding site was recently reported as susceptibility allele at PSORS2 (17q25) in cohorts of psoriasis patients from the US. A testing of this variant in psoriasis patients from Germany did not confirm this association in 300 trios nor in two case-control studies with 281 patients with psoriasis vulgaris and 375 patients with psoriatic arthritis, respectively. These results fail to support rs734232 as a psoriasis susceptibility factor in German psoriasis patients.

Published 18 January 2005 in J Invest Dermatol, 124(1): 107-10.
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